Articles Tagged With:
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Seizures in Adolescents: Motor or Nonmotor?
The rate at which motor vs. nonmotor seizures are recognized in adolescents is unknown. This retrospective analysis demonstrates a high rate of misrecognition of nonmotor seizures among adolescents presenting to an emergency department and frequent misrecognition of any nonmotor seizures in those presenting with a first-time motor seizure.
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Novel Gene Therapy for Giant Axonal Neuropathy
The authors conducted a Phase I trial of a gene editing approach delivered by adeno-associated virus vector carrying a codon-optimized human giant axonal neuropathy transgene. The transgene targets anterior horn motor neuron bodies and sensory neurons in the dorsal root ganglia with the goal of repairing peripheral nerves and their axons. Each patient received a single intrathecal injection of the investigational agent. At one year, patients had less progression of disease compared to pretreatment intervals.
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Ceftobiprole Medocaril Sodium for Injection (Zevtera)
The U.S. Food and Drug Administration has approved a new cephalosporin antibacterial for the treatment of three serious infections: bloodstream, skin and skin structure, and community-acquired pneumonia. Ceftobiprole is a fifth-generation cephalosporin with in vitro activity against gram-positive and gram-negative bacteria including multidrug resistant organisms. It will be distributed by Basilea Pharmaceutica International Ltd, Allschwil as Zevtera.
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Another Step in the Journey to Combat Diagnostic Errors in Hospitalized Patients
Diagnostic errors in hospitalized patients who died or were transferred to the intensive care unit were common in this large retrospective, multicenter trial and frequently associated with patient harm. Problems with clinical assessment and ordering and interpreting tests were the most prevalent diagnostic process faults, with sepsis the diagnosis most associated with diagnostic error.
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Increased Risk of Morbidity with Prolonged Use of PPIs Without an Indication Post-ICU
In previously critically ill adults, the use of a proton pump inhibitor without an indication for more than eight weeks increased morbidity and mortality.
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The Burden of Clostridioides difficile Infection
This article outlines the clinical, social, and economic burden of Clostridioides difficile infection (CDI) in the United States and its shifting epidemiology.
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Inappropriate Diagnosis of Pneumonia Is Common in Hospitalized Patients
A cohort study that included 48 hospitals in Michigan found that 12% of patients treated for community-acquired pneumonia were diagnosed inappropriately. Older age, dementia, and presenting with acute change in mental status increased the risk for misdiagnosis.
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Ethical Obligations if Patients Have Limited English Proficiency
As a nurse and clinical bioethicist, Melissa Kurtz Uveges, PhD, MA, RN, had a strong desire to facilitate communication with patients with Limited English Proficiency and to provide information in their preferred language.
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Electronic Order Set Facilitates Treatment Withdrawal
At OhioHealth, an electronic order set is used to facilitate withdrawal of life-sustaining treatment.
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Most Financial Conflicts of Radiology Guideline Authors Are Undisclosed
Even though the federal Physician Payments Sunshine Act was enacted more than a decade ago, misconceptions persist as to its requirements.